Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use

CS Bradshaw; LA Vodstrcil; JS Hocking; M Law; M Pirotta; SM Garland; D De Guingand; AN Morton; CK Fairley

Journal article

Recurrence of bacterial vaginosis is significantly associated with posttreatment sexual activities and hormonal contraceptive use

CS Bradshaw, LA Vodstrcil, JS Hocking, M Law, M Pirotta, SM Garland, D De Guingand, AN Morton, CK Fairley

Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2013

DOI: 10.1093/cid/cis1030

Abstract

Background. Bacterial vaginosis (BV) recurrence posttreatment is common. Our aim was to determine if behaviors were associated with BV recurrence in women in a randomized controlled trial (RCT). Methods. Symptomatic 18- to 50-year-old females with BV (≥3 Amsel criteria and Nugent score [NS] = 4-10) were enrolled in a 3-arm randomized double-blind RCT Melbourne Sexual Health Centre, Australia, in 2009-2010. All 450 participants received oral metronidazole (7 days) and were equally randomized to vaginal clindamycin, lactobacillus-vaginal probiotic or vaginal placebo. At 1, 2, 3, and 6 months, participants self-collected vaginal smears and completed questionnaires. Primary endpoint was NS = 7-1..

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University of Melbourne Researchers

Catriona Bradshaw Author

Lenka Vodstrcil Author

Jane Hocking Author

Suzanne Wark Author

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Grants

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council Project (grant number APP454644); by the Australian National Health and Medical Research Council (fellowship numbers APP 456164 and 566576 to C. S. B. and J. S. H., respectively); and by a Primary Health Care Research Evaluation and Development Mid-career Fellowship, Department of Health and Aging (to M. P.).